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Clara cell secretory protein

Clara cell secretory protein (CC16): features as a

Clara cell protein (CC16 or CC10) is a 15.8-kDa protein secreted all along the tracheobronchial tree and especially in the terminal bronchioles where Clara cells are localized. Even though the exact in vivo function of CC16 remains to be clarified, evidence is accumulating that CC16 plays an importa Clara cell secretory protein (CCSP) is a product of nonciliated cells of the conducting airway epithelium. The normal physiological function of CCSP is unknown

Clara cell secretory protein: a determinant of PCB

  1. Clara cell secretory protein The bronchioles are a major target for tobacco smoke exposure, and a significant decrease in the number of Clara cells is seen there in individuals who smoke. 1 In nonsmoking individuals, Clara cells account for 8% of the cells lining the bronchioles (range, 2 to 14%)
  2. The aim of this study was to assess the serum concentrations of Clara cell secretory protein (CC16) in association with acute and chronic lung injury in mechanically ventilated preterm neonates. Thirty-five preterm neonate
  3. Clara cell secretory protein (CCSP) is one protein that is synthesized, stored (in secretory granules) and secreted by Clara cells. CCSP may be an important defense protein in the lung, as in vitro studies suggest that it modulates inflammation and binds reactive cytotoxicants

Clara cell secretory protein. Gene. ccsp. Organism. Neotomodon alstoni (Mexican volcano mouse) (Peromyscus alstoni) Status. Unreviewed-Annotation score: -Protein predicted i. Names & Taxonomy i. Protein names i: Submitted name: Clara cell secretory protein Imported. Gene names i: Name:ccsp Imported. In a major step towards combating issues affecting equine reproduction and respiration, researchers at the University of Guelph have identified a protein called Clara cell secretory protein (CCSP) that may assist in developing better defence systems when it comes to treatment and prevention Clara cell secretory protein (CCSP) is one of the most abundant proteins of the airway lining fluid Summary Background Previously, an association has been reported between an increased risk of asthma and a polymorphism in the Clara cell secretory protein (CC16) gene [namely, an adenine to guanine substitution in the CC16 gene at position 38 (A38G) downstream from the transcription initiation site within the noncoding region of exon 1] Abbreviation: CCSP Clara cell secretory protein The bronchioles are a major target for tobacco smoke exposure, and a significant decrease in the number of Clara cells is seen there in individuals who smoke.1 In nonsmoking individuals, Clara cells account for 8% of the cells lining the bronchioles (range,2to14%).1 InBALfluidfromsmokers,lowe

Clara cell protein (CC16) is a 15.8‐kDa homodimeric protein secreted in large amounts in airways by the non‐ciliated bronchiolar Clara cells. This protein increasingly appears to protect the respiratory tract against oxidative stress and inflammation clara cell secretory protein(CCSP) is a 10-kDa dimeric protein synthesized primarily by nonciliated bronchiolar epithelial cells (11). CCSP is one of the most abundant soluble proteins within the epithelial lining fluid of the lung (11) This antiparallel disulfide linked homodimeric protein is multifunctional and found in various tissues in various names such as: uteroglobin (UG, UGB), uteroglobin-like antigen (UGL), blastokinin, club-cell secretory protein (CCSP), Clara-cell 16 kD protein (17 in rat/mice), club-cell-specific 10 kD protein (CC10), human protein 1, urine. Clara cell secretory protein (CCSP), also referred to as CC10, CC16, or uteroglobin.2 This protein is the prototypic member 1A1 of the secretoglobin (SCGB) family.2 CCSP is a steroid-inducible homodimer secreted by epithelial cells. In humans, highest expression is in lung and uterus, with lesse One of these proteins is the Clara cell secretory protein, a low-molecular-weight protein of 16 kDa (CC16), secreted in large amounts into the lumen of the respiratory tract by nonciliated bronchiolar Clara cells 13, 14

Inflammation & Autoimmune Mechanisms Detect Clara Cell Secretory Protein using this Anti-Clara Cell Secretory Protein Antibody validated for use in IH & WB Clara cell secretory protein is a 16-kD homodimeric secretory protein expressed abundantly by nonciliated airway epithelial (Clara) cells of the lung (23 - 25) Club cell (formerly Clara cell) protein or CC16 (also known as CC10, club cell secretory protein, and uteroglobin) is a member of the secretoglobin family of small disulphide bridge dimeric proteins

Clara Cell Secretory Protein - CHES

  1. oglycans to protect the bronchiole lining
  2. Two candidate stem cells were identified on the basis of proliferative potential after chemical ablation: a pollutant-resistant subpopulation of Clara cells that retain their expression of Clara cell secretory protein (CCSP) (variant CCSP-expressing [CE] cells or vCE cells) and calcitonin gene-related peptide (CGRP)-expressing pulmonary.
  3. al bronchioles where Clara cells are localized. Even though the exact in vivo function of CC16 remains to be clarified, evidence is accumulating that CC16 plays an important protective role in the respiratory tract against oxidative stress and inflammatory.
  4. The major secretory product of Clara cells is a nonglycosylated low molecular weight (10-kd reduced, 16-kd nonreduced) protein designated Clara cell secretory protein (CCSP), also referred to as CC10, CC16, or uteroglobin. 2 This protein is the prototypic member 1A1 of the secretoglobin (SCGB) family. 2 CCSP is a steroid-inducible homodimer.
  5. Clara cell secretory protein (CC16): characteristics and perspectives as lung peripheral biomarker. Clin Exp Allergy. 2000; 30(4):469-75 (ISSN: 0954-7894) Broeckaert F; Bernard A. Clara cell protein (CC16) is a 15.8-kDa homodimeric protein secreted in large amounts in airways by the non-ciliated bronchiolar Clara cells
  6. onors and recipients in a longitudinal study cohort of 63 consecutive lung transplant recipients (LTR) with a median follow-up of 493 days (range, 26-894). Clara cell secretory protein (CCSP) and interleukin 8 levels were assessed in the bronchoalveolar lavage and plasma at 1, 3, 6, and 12 months after transplantation. CCSP-positive cells were assessed in transbronchial biopsies at 1 and 3.

Clara cell secretory protein (CC16) as a peripheral blood

Clara cell secretory protein (CCSP) is one of the most abundant proteins in the airway surface fluid, and has many putative functions. Recent advances in the field of stem cells and lung regeneration have identified potentially new roles of CCSP and CCSP-expressing cell populations in airway maintenance, repair and regeneration. This review focuses on the airway regenerative potential of CCSP. Clara cell secretory protein (CCSP) is a 10-kDa protein first isolated from rodent lung lavage and shown by immunohis-tochemistry to localize to secretory granules of Clara cells lining the bronchiolar epithelium (8). Although the precise biological role of CCSP is unknown, the amino acid sequence of this protein is homologous to rabbit. Clara cell secretory protein (CCSP) is an immune-modulating and anti-inflammatory agent. CCSP is available synthetically as recombinant human Clara cell protein (rhCC10). It has been shown in animal models to reduce lung injury, improve pulmonary compliance and oxygenation, decrease systemic inflammation and up-regulate surfactant protein and.

(PDF) Pulmonary Cytochrome P450 Monooxygenase and Clara

Clara cell secretory protein (CCSP)1 is a small homodimeric protein consisting of two 8-kDa subunits linked by disulfide bridges (reviewed in Ref. 1). The protein is predominantly produced in Clara cells, a non-ciliated cell type in the bronchio-lar epithelium of the lung, and is secreted into the airway lumen Highly purified Clara cells (93 +/- 3%) isolated from the lungs of rabbits were used to produce an antiserum against Clara cell secretory proteins. This antiserum was used to identify and study the biosynthesis and secretion of [35S]methionine-labeled proteins from isolated Clara cells Clara cell secretory protein (CCSP) is one of the most abundant proteins in the airway surface fluid, and has many putative functions. Recent advances in the field of stem cells and lung regeneration have identified potentially new roles of CCSP and CCSP-expressing cell populations in airway maintenance, repair and regeneration Clara cell secretory. protein (CCSP) counters inflammation in the lung, hence we hypothesized that CCSP depletion is a key. feature of RAO in horses. Recombinant equine CCSP and specific antiserum. Abstract. A novel gene that is down-regulated in lungs of T/ebp/Nkx2.1-null mouse embryos has been identified using a suppressive-subtractive hybridization me

Clara Cell - an overview ScienceDirect Topic

Clara cell secretory protein (CCSP) is a transport protein for lipophilic substances in bronchio-alveolar fluid, plasma, and uterine secretion. It acts as a carrier for steroid hormones and polychlorinated biphenyl metabolites. Previously, the existence of receptors for uptake of CCSP·ligand complexes into the renal proximal tubules had been suggested Clara cells are non-ciliated, secretory bronchiolar epithelial cells that serve to detoxify harmful inhaled substances. Clara cells also function as stem/progenitor cells for repair in the bronchioles. Clara cell secretory protein (CCSP) is specifically expressed in pulmonary Clara cells and is widely used as a Clara cell marker. In addition CCSP promoter is commonly used to direct gene. Clara cell protein (CC16) is a 16-kDa protein secreted by Clara cells and other nonciliated cells of both the bronchiolar and bronchial epithelium. CC16 is present in high concentrations in the. Serum Clara cell secretory protein (CC-16) in non-smoking patients with obstructive sleep apnea. Mar 9, 2020 This study aimed to determine the association between the severity of obstructive sleep apnea (OSA) and serum Clara cell protein (CC16) levels in non-smoking patients with OSA

ccsp - Clara cell secretory protein - Neotomodon alstoni

  1. al bronchioles of the lung. CCSP gene expression is an informative developmental marker within the bronchiolar epithelium recapitulating cellular differentiation in the distal respiratory.
  2. al bronchioles [1,2,3].Although the physiological function of CC16 is unknown, there is evidence of protective anti-inflammatory and immunosuppressive properties against inadequate activation of the immune system which may cause tissue damage [4,5,6]
  3. Club cell secretory protein-16 (CC16) is the major secreted product of airway club cells, but its role in the pathogenesis of chronic obstructive pulmonary disease (COPD) is unclear. We measured CC16 airway expression in humans with and without COPD and CC16 function in a cigarette smoke (CS)-induced COPD murine model. Airway CC16 expression was measured in COPD patients, smokers without COPD.
  4. Clara cell secretory protein (CCSP; also known as CC16, CC10 and uteroglobin) is a 16-kDa homodimeric protein that is secreted by non-ciliated bronchiolar (Clara) cells into the mucus lining the bronchial epithelium of the mammalian lung. It is one of the most abundant proteins in the airway mucus of mammals . As a biomarker of Clara cells and.
  5. The Clara cell secretory protein (CCSP) imparts a protective effect to the lung during oxidant injury. However, exposure to supplemental oxygen, a common therapeutic modality for lung disease, represses the expression of CCSP in the adult mouse lung. We investigated the mechanisms of hyperoxia-induced repression of the mouse CCSP promoter. Deletio
  6. Decreased Clara cell secretory protein (CCSP) levels have been found in smokers and chronic obstructive pulmonary disease (COPD) patients, which may be related to the development of COPD. A phosphodiesterase-4 (PDE4) inhibitor, roflumilast, appears to have therapeutic value for COPD
  7. The expression of clara cell secretory protein in BAL fluid of patients with idiopathic interstitial pneumonia Sang Won Um, Seon Jin Han, Chang Min Choi, Chang Hoon Lee , Chul Gyu Yoo , Choon Taek Lee , Sung Koo Han , Young Soo Shim, Young Whan Ki

We have previously reported a subpopulation of bone marrow cells (BMC) that express Clara cell secretory protein (CCSP), generally felt to be specific to lung Clara cells. Ablation of lung Clara cells has been reported using a transgenic mouse that expresses thymidine kinase under control of the CCSP promoter. Treatment with ganciclovir results in permanent elimination of CCSP+ cells, failure. adshelp[at]cfa.harvard.edu The ADS is operated by the Smithsonian Astrophysical Observatory under NASA Cooperative Agreement NNX16AC86

Report on Research: Clara Cell Secretory Protein

  1. Clara cell secretory protein (CCSP; also known as CC16, CC10 and uteroglobin) is a 16-kDa homodimeric protein that is secreted by non-ciliated bronchiolar (Clara) cells into the mucus lining the bronchial epithe-lium of the mammalian lung. It is one of the most abun-dant proteins in the airway mucus of mammals [8]. As
  2. Clara cell secretory protein (CCSP) counters inflammation in the lung, hence we hypothesized that CCSP depletion is a key feature of RAO in horses. Recombinant equine CCSP and specific antiserum were produced, and percutaneous lung biopsies were obtained from 3 healthy horses and from 3 RAO-affected horses before and after induction of RAO.
  3. e serum CC16's relation to asthma aetiology and exacerbation. There is evidence that acute exposures to certain pulmonary irritants can cause a transient increase in serum CC16 levels, and.

Secretory Protein - an overview ScienceDirect Topic

(A) A mouse line containing the Clara cell secretory

An association study between the Clara cell secretory

CC10, composing seven percent of the total protein in normal bronchioloalveolar lavage fluid, is the major protein product of the nonciliated secretory or Clara cells that are precursors for. Clara cell secretory protein (CCSP), also known as uteroglobin (Ug), is a 16-kDa homodimeric protein of unknown function. Within rodent species, CCSP is expressed predominantly by nonciliated Clara cells that line conducting airways of the lung. To investigate in vivo functions for CCSP, we established mice homozygous for a null allele of the CCSP gene (CCSP−/−) CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Clara cells represent the predominant secretory cell within distal conducting airways of mammals and exhibit functional alterations with chronic lung disease. We previously demonstrated that Clara cell secretory protein (CCSP) deficiency results in enhanced susceptibility to environmental agents

Related abbreviations. The list of abbreviations related to CCSP - Clara cell secretory protein Clara cell secretory protein (CCSP) is an abundant 10-kDa protein synthesized and secreted by nonciliated epithelial cells lining the respiratory and terminal bronchioles of the lung. CCSP gene expression is an informative developmental marker within the bronchiolar epithelium recapitulating cellular differentiation in the distal respiratory epithelium during late fetal and early postnatal life Little is known about the molecular basis for differential pulmonary oxidant sensitivity observed between genetically disparate members of the same species. We have generated mice that are deficient in Clara cell secretory protein (CCSP -/-) and that exhibit an oxidant-sensitive phenotype

Clara Cell Secretory Protein - CHEST Hom

Safety Data Sheet for Anti-Clara Cell Secretory Protein Antibody 07-623. Material Safety Data Sheet or SDS for Anti-Clara Cell Secretory Protein Antibody 07-623 from MilliporeSigma for download or viewing in the browser. Catalog Number 07-623. Product Name Anti-Clara Cell Secretory Protein Antibody. Select Language Clara cell protein (CC16) is a 15.8-kDa homodimeric protein secreted in large amounts in airways by the non-ciliated bronchiolar Clara cells. This protein increasingly appears to protect the respiratory tract against oxidative stress and inflammation The Role of Clara Cells and Clara Cell Secretory Protein. Radiat. Res. 179, 617-629 (2013). Viral infections have been associated with exacerbation of disease in human cases of idiopathic pulmonary fibrosis. Since pulmonary fibrosis is a common outcome after irradiation to the lung, we hypothesized that viral infectio In addition to the major Clara cell secretory protein (CCSP), also known as CC10, CC16, Clara cell antigen, secretoglobin 1A1 (SCGB1A1) or uteroglobin, Clara cells also contribute surfactant apoproteins A, B and D, proteases, anti-microbial peptides, several cytokines and chemokines, and mucins in the extracellular fluid lining airspaces Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung. L Zhou, L Lim, R H Costa, and J A Whitsett Journal of Histochemistry & Cytochemistry 1996 44 : 10 , 1183-119

Clara‐cell secretory protein (CCSP), produced primarily by Clara cells in the conducting airways, is the most abundant soluble protein in pulmonary lavage fluid. CCSP is thought to be an immunosuppressive or anti‐inflammatory protein with protective functions in the respiratory tract against exaggerated inflammatory reactions. CCSP was measured in 98 tracheoalveolar fluid (TAF) samples. These epithelial cells secrete several distinctive proteins, including Clara cell 10-kDa secretory protein (CCSP) The Clara cells are a group of cells, sometimes called nonciliated bronchiolar secretory cells, found in the bronchiolar epithelium of mammals including man, and in the upper airways of some species such as mice Clara. It was discovered that Clara cells secretory protein (CC16) protects against pro-inflammatory effect of phospholipase A2 and C, likely as an effect of an interplay between CC16 and phospholipid vesicles and disturb binding of phospholipases to the phospholipids [23,24] Clara cells are non-ciliated, secretory bronchiolar epithelial cells that serve to detoxify harmful inhaled substances. Clara cells also function as stem/progenitor cells for repair in the bronchioles. Clara cell secretory protein (CCSP) is specifically expressed in pulmonary Clara cells and is widely used as a Clara cell marker

Clara's Cell | Dale Leschnitzer | Flickr

The highly secretory Clara cells play a pivotal role in protecting the lung against inflammation and oxidative stress. This study reports the positional cloning of a novel protein required for Clara cell physiology in mouse lung development. The perinatal lethal N -ethyl- N -nitrosourea-induced l7Rn64234SB allele contained a nonsense mutation in the previously hypothetical gene NM_026304 on. Project Methods The PI will provide morphometric and ultrastructure analysis of lungs of mice with the gene for Clara cell secretory protein ablated. Progress 09/01/00 to 08/31/05 Outputs This collaborative project with Dr. Barry Stripp at University of Pittsburgh (formerly of University of Rochester) has been completed

against Claracell secretory proteins. This antiserumwasusedto identify andstudythebiosynthesis and secretion of [3S]methionine-labeled proteins from isolated Clara cells. The antiserum recognized one major secretory protein with apparent molecular weight of 6 kDa and reacted weakly with a higher molecularweightproteinofabout 180kDa Clara cell secretory protein (CCSP), or CC10, is an inhibitor of secretory phospholipase A 2 which may be produced by phagocytic cells and by a variety of other cells in the airway. Tumor necrosis factor-a (TNF-a Clara Cell Markers . Clara cells are non-mucous and non-ciliated secretory cells found in the primary bronchioles of the lungs, and were originally described by their namesake, Max Clara in 1937.. Clara cells are dome-shaped and have short microvilli. One of the main functions of Clara cells is to protect the bronchiolar epithelium The cells that are located in the distal airway are clara cells, which have a hemispherical shape with microscopic hair-like strands called microvilli. A primary task performed by clara cells is to guard the bronchial tissue against damage often caused by pollutants. The cells secrete a secretory protein and promote detoxification of the lungs The Clara cells are a group of cells, sometimes called nonciliated bronchiolar secretory cells, found in the bronchiolar epithelium of mammals including man, and in the upper airways of some species such as mice.The chemical nature of the secretion probably includes protein, glycoprotein and lipids

Detect Clara Cell Secretory Protein using this Anti-Clara Cell Secretory Protein Antibody validated for use in IH & WB. - Find MSDS or SDS, a COA, data sheets and more information Considering the defensive role of both Clara cell secretory proteins and ANXA1 in the respiratory apparatus, and the importance of salivary gland secretion in the first line of oral defence, we decided to evaluate the expression of CC10, CC26 and ANXA1 proteins in rat major salivary glands using immunohistochemistry Lung vascular permeability is acutely increased by high-pressure and high-volume ventilation. To determine the roles of mechanically activated cytosolic PLA2 (cPLA2) and Clara cell secretory protein (CCSP), a modulator of cPLA2 activity, we compared lung injury with and without a PLA2 inhibitor in wild-type mice and CCSP-null mice (CCSP-/-) ventilated with high and low peak inflation pressures. (2003). Lung Hyperpermeability, Clara-Cell Secretory Protein (CC16), and Susceptibility to Ozone of Five Inbred Strains of Mice. Inhalation Toxicology: Vol. 15, No. 12, pp. 1209-1230 Clara cell secretory protein of 10-16 kDa (CC16), also known as CC10, Club cell protein, CCSP, or uteroglobin [9, 10], a member of the secretoglobin family , is the most abundant protein in bronchoalveolar lavage (BAL) fluid or tracheal aspirates (TA) from neonates [12, 13]

The Clara cell secretory protein (CCSP) imparts a protective effect to the lung during oxidant injury. However, exposure to supplemental oxygen, a common therapeutic modality for lung disease, repres.. Clara cell secretory protein (CCSP), also known as uteroglobin (Ug), is a 16-kDa homodimeric protein of unknown function. Within rodent species, CCSP is expressed predominantly by nonciliated Clara cells that line conducting airways of the lung. To investigate in vivo functions for CCSP, we established mice homozygous for a null allele o

CC10 is a member of the secretoglobin family assigned to subgroup 1A1, known by many other names such as Clara cell secretory protein 16 (CC16 or CCSP), uteroglobin, urine protein-1, human protein 1, and polychlorinated biphenyl-binding protein Stripp, Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion, The American Journal of Respiratory Cell and Molecular Biology, vol Serum levels of Clara cell secretory protein, asthma, and lung function in the adult general population. Marta Rava, Lluisa Taresa, Iris Lavi, Esther Barreiro, Jan Paul Zock, Anna Ferrer, Nerea Muniozguren, Rachel Nadif, Lucia Cazzoletti, Francine Kauffmann, Josep M. Anto, Stefano Guerra localization to bronchiolar nonciliated secretory Clara cells, implicating these cells in the local regulation of electrolyte/ water transport in airway epithelia. MATERIALSANDMETHODS Peptide Synthesis, Immunization Procedure, and Antisera. From the published proguanylin sequence (2-5), the peptides guanylin-(34-46), guanylin-(101-115), and. Background Pulmonary Clara cell secretory 10-kd protein (CC10) is a steroid-inducible and potentially anti-inflammatory cytokine, but its direct involvement in the regulation of T-cell responses remains unknown. Objective The role of CC10 in the regulation of T H 2 cytokine expression was investigated. Methods The levels of cytokine and GATA-3.

Clara cell secretory protein expression changes is a relevant marker in the development of bronchiolitis obliterans patients with lung transplantation. PMID: 22883104; Overview of CC16 in pathophysiology of and as a biomarker in chronic obstructive pulmonary disease. PMID: 2303058 Uteroglobin, also called Clara cell secretory, phospholipid binding, 10 kDa or 16 kDa protein (CCSP, CCPBP, CC10 or CC16, respectively) is a small, non-glycosylated secreted protein of the secretoglobin superfamily, (designated 1A, member 1) (1 - 3). Its name is derived from its very high expression in the pre-implantation uterus Club cell secretory protein (Clara), or CC16 (encoded by the SCGB1A1 gene), is a 16 kDa protein that belongs to the secretoglobin superfamily and, although it can be found in the urogenital tract, is mainly produced by bronchiolar club cells, which account for most of its concentration in blood Clara cells represent the predominant secretory cell within distal conducting airways of mammals and exhibit functional alterations with chronic lung disease. We previously demonstrated that Clara cell secretory protein (CCSP) deficiency results in enhanced susceptibility to environmental agents

In addition, when placed in small airway growth media, pHLP cell cultures depict the expression of aquaporin 5 and Clara cell secretory protein, which is identified with that of alveolar type I epithelial cells and Clara cells, respectively, thereby exhibiting the capacity to potentially differentiate into airway epithelial cells Abstract. Clara cells are nonciliated secretory cells lining the respiratory epithelium and are easily identified by the expression of Clara cell secretory protein (CCSP). To investigate molecular mechanism (s) regulating Clara cell function in the lungs, Cre recombinase was inserted into exon 1 of the CCSP, generating two novel mouse models.

Clara cell secretory protein (CCSP) is an abundant 16-kDa homodimeric protein and is secreted by non-ciliated secretory epithelial cells in the lung. It has an important protective role against the intrapulmonary inflammatory process. The aim of this study was to investigate the expression of CCSP in endotoxin-induced otitis media with effusion. US Biological Anti-Clara Cell Protein SKU: 030105() PCR, Cloning & Expressio See Stripp et al. (1994) for a discussion of the relationship between Clara cell secretory protein and uteroglobin, as well as a discussion of the murine gene. Gene Structure Menne et al. (1982) showed that the UGB gene spans 3 kb and comprises 3 exons and 2 introns Club cell secretory protein (CC16) is encoded by the SCGB1A1 gene. It is also known as CC10, secretoglobin, or uteroglobin. CC16 is a 16 kDa homodimeric protein secreted primarily by the non-ciliated bronchial epithelial cells, which can be detected in the airways, circulation, sputum, nasal fluid, and urine. The biological activities of CC16 and its pathways have not been completely. Clara cells are mainly located in the respiratory bronchioles and they have granules containing various proteins. One of these secretory proteins is Clara cell 16 kD secretory protein (CC16), which is referred to in literature by various names such as uteroglobin (UG), blastokinin, Clara cell secretory protein (CCSP), Clara cell-specific 10 kD.

CC16 stands for Clara Cell Secretory Protein 16. Suggest new definition. This definition appears rarely and is found in the following Acronym Finder categories: Science, medicine, engineering, etc. Link/Page Citation Abbreviation Database Surfer. Clara cells are not ciliated. Clara cells are non-ciliated, non-mucous, secretory cells in respiratory epithelium. By light microscopy, Clara cells are morphologically columnar to cuboidal with a distinctive dome-shaped luminal surface and con.. The findings, published today in the journal Cell, come at a time when new coronavirus cases are surging worldwide, with related U.S. deaths nearing 225,000. Scientists have known for some time that viruses enter and infect cells and then use the cell's protein-making machinery to make multiple copies of themselves before escaping the cell The Clara cell markers, CCSP and Cyp2f2, were measured in the lung by qRT-PCR, and protein expression was visualized in the lung by immunofluorescence. Following pulmonary function tests, mice were sacrificed and tissues were collected for pathological analysis

Video: Clara cell secretory protein decreases lung inflammation

Clara cell secretory protein decreases lung inflammationEvidence for Human Lung Stem Cells | NEJM