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Pathophysiology of neonatal jaundice ppt

Neonatal jaundice - SlideShar

  1. Neonatal Jaundice (Hyperbilirubinemia) • Definition: Hyperbilirubinemia refers to an excessive level of accumulated bilirubin in the blood and is characterized by jaundice, a yellowish discoloration of the skin, sclerae, mucous membranes and nails. • Unconjugated bilirubin = Indirect bilirubin. • Conjugated bilirubin = Direct bilirubin
  2. Neonatal Jaundice(also called Newborn jaundice) is a condition marked by high levels of bilirubin in the blood. The increased bilirubin cause the infant's skin and whites of the eyes (sclera) to look yellow. 4. Billirubin Metabolism 5. Special characteristic in neonates • 1.More billirubin produced • Much more Hemolysis • The life.
  3. Neonatal Jaundice first becomes visible in the face and forehead. Blanching reveals the underlying colour. Jaundice then gradually becomes visible on the trunk andextremities. SIGNS AND SYMPTOMS OF NEONATAL JAUNDICE Newborns, asthe bilirubin level rises, jaundice will typically progress from the head to the trunk, and then to the hands and feet
  4. Pathophysiology of jaundice. 1. PATHOPHYSIOLOGY OF JAUNDICE. 2. JAUNDICEYellow Pigmentation of skin and sclera by bilirubin.Nl bilirubin level -.3-1.3mg/dLManifested when pl. bilirubin level exceeds 3mg/dL. 3. METABOLISM OF BILIRUBINDestruction of red cells haembiliverdin bilirubin (uncon) BMG BDG Stercobilinogen urobilinogen. 4
  5. Neonatal Jaundice - Prof. Sirota Lea Department of Neonatology Shnaider Children s hospital Physiologic Jaundice Healthy infants up to 12mg% in 3rd day; in premature, 5th day

Neonatal Phototherapy Devices Market 2017-2027 by Top Key Players- General Electric Company, Atom Medical Corporation, Medela AG, Phoenix Medical Systems Pvt Ltd - The World Health Organization estimated in 2015 that 4/5th of preterm infants developed jaundice. Preterm birth rates can be as high as 7% in developed countries and are even higher in developing ones Presentation of Jaundice Pathophysiology of jaundice Pre -hepatic o Increased breakdown of red cells leads to increased serum bilirubin. This unconjugated bilirubin isn't water-soluble so can't be excreted in the urine. Intestinal bacteria convert some of the extra bilirubin into urobilinogen, some of which is re-absorbed and IS excrete Pathophysiology Of Jaundice Ppt, Pathogenesis And Management Of Indirect Hyperbilirubinemia In Preterm Neonates Less Than 35 Weeks Moving Toward A Standardized Approach American Academy Of Pediatrics Pathophysiology of jaundice ppt Indeed recently has been sought by consumers around us, maybe one of you personally

Neonatal Jaundice - SlideShar

For these reasons, the presence of neonatal jaundice frequently results in diagnostic evaluation. Neonatal jaundice may have first been described in a Chinese textbook 1000 years ago. Medical theses, essays, and textbooks from the 18 th and 19 th centuries contain discussions about the causes and treatment of neonatal jaundice. Several of these. Jaundice comes from the French word jaundice, which means yellow; thus a jaundiced baby is one whose skin color appears yellow due to bilirubin. Bilirubin level of more than 85 umol/l (5 mg/dL) manifests clinical jaundice in neonates whereas in adults a level of 34 umol/l (2 mg/dL) would look icteric. Predisposing causes of Neonatal Jaundice Neonatal jaundice III. Polycythemia IV. Extra vascular blood • Cephalohematoma • Sub‐galeal hematoma • Intraventricular bleed • Subarachnoid bleed V. Increased enterohepatic circulation • Intestinal obstruction. 7 April 2016* IAP UG Teaching slides 2015‐16 CAUSES OF JAUNDICE IN NEWBORN -.

A PRESENTATION BY MARY NYAMBURA MUONGOYA DEFINITION Neonatal jaundice refers to the yellowish discoloration of the white part of the eyes (sclera) and skin in a newborn baby due to bilirubin deposition in these tissues secondary to high serum bilirubin levels (hyperbilirubinemia) that occurs when the rate of production exceeds the rate of elimination Jaundice is the most common morbidity in the first week of life, occurring in 60% of term and 80% of preterm newborn. Jaundice is the most common cause of readmission after discharge from birth hospitalization.1 Jaundice in neonates is visible in skin and eyes when total serum bilirubin (TSB) concentration exceeds 5 to 7 mg/dL Introduction. Jaundice is t he yellow colouring of skin and sclera caused by the accumulation of bilirubin in the skin and mucous membranes.. Neonatal jaundice occurs in 60% of term infants and 80% of preterm infants [1] and is caused by hyperbilirubinaemia that is unconjugated (divided into physiological or pathological) or conjugated (always pathological). ). High levels of unconjugated. What is Jaundice • Neonatal jaundice • Definition • Neonatal jaundice is the term used when a newborn has an excessive amount of bilirubin in the blood. Bilirubin is a yellowish-red pigment that is formed and released into the bloodstream when red blood cells are broken down. Jaundice comes from the French word jaune, which mean PPT - Jaundice PowerPoint presentation | free to download Jaundice - My Free Prescription - Jaundice is a yellow mark of the Page 4/10. presentation of jaundice pathophysiology of jaundice as a result simple! offers an array of book printing services, library book Bilirubin (bil-ih-ROO-bin) is the substance that causes yellowing of the skin and.

PPT - NEONATAL JAUNDICE PowerPoint Presentation - ID:152867

Breast milk jaundice: Distinct from breastfeeding jaundice, breast milk jaundice develops in the second week of life, lasts longer than physiologic jaundice, and has no other identifiable cause. Pathophysiology is not well understood, but it is thought that substances in breast milk, such as beta-glucuronidases and nonesterified fatty acids. Neonatal jaundice pathophysiology On the Web Most recent articles. Most cited articles. Review articles. CME Programs. Powerpoint slides. Images. American Roentgen Ray Society Images of Neonatal jaundice pathophysiology All Images X-rays Echo & Ultrasound CT Images MRI; Ongoing Trials at Clinical Trials.gov. US National Guidelines Clearinghouse. Results: Neonatal jaundice due to breast milk feeding is also sometimes observed. Hemolytic jaundice occurs because of the incompatibility of blood groups with ABO and Rh factors, when the fetus and mother blood groups are not compatible and the fetus blood crosses the barrier of the umbilical cord before birth causing fetus blood hemolysis owing to severe immune response The incidence of prolonged jaundice is approximately 2-4 % of all deliveries. 90% of babies with prolonged jaundice are breast fed. There are many causes of prolonged jaundice the commonest being 'breast milk jaundice' - a normal physiological variation. However there are rarer and more significant causes

Learn and Enjoy!This channel is for educational purposes only! Error: Heme oxygenase, not heme oxidase. 5:30You can donate via Venmo or Cash App to support t.. Jaundice is a yellow discoloration of the skin and eyes caused by hyperbilirubinemia (elevated serum bilirubin concentration). The serum bilirubin level required to cause jaundice varies with skin tone and body region, but jaundice usually becomes visible on the sclera at a level of 2 to 3 mg/dL (34 to 51 micromol/L) and on the face at about 4 to 5 mg/dL (68 to 86 micromol/L)

Infant jaundice is yellow discoloration of a newborn baby's skin and eyes. Infant jaundice occurs because the baby's blood contains an excess of bilirubin (bil-ih-ROO-bin), a yellow pigment of red blood cells. Infant jaundice is a common condition, particularly in babies born before 38 weeks' gestation (preterm babies) and some breast-fed babies Overview. Neonatal jaundice describes a condition in which an infant's skin appears yellow within the first few days of life. The yellowish appearance is a sign of an increased blood pigment called Bilirubin, which then settles in the skin.In many cases this is a normal process and occurs in about 2/3 of all healthy newborns Neonatal Jaundice 731248 PPT. Presentation Summary : Neonatal Jaundice. Download more documents and slide shows on The Medical Post [ ] Dr. KalpanaMalla. MD Pediatrics This video looks at neonatal jaundice, a yellowish discoloration of the white part of the eyes and skin in a newborn baby due to high bilirubin levels

Transcript Neonatal Jaundice.ppt. Neonatal Jaundice Dr. AbdulRahman Al Nemri, MD Chairman of Pediatric Department Associate Professor Senior Consultant Neonatologist Introduction Yellow-orange pigment Icterus - ikteros - bilirubin in the skin and sclerae. It affects 60% of neonates. Jaundice = galbus (it appears when TSB is more than 34umol/l. Neonatal hyperbilirubinemia is an elevated serum bilirubin. level in the neonate. The most common type is unconjugated. hyperbilirubinemia, which is visible as jaundice in the first. week of life. Although 60% of babies will develop jaundice, and most. jaundice is benign, severe hyperbilirubinemia can cause View Pathophysiology of Neonatal Jaundice.docx from BIO 3313 at Fort Scott Community College. Brooke D. Mathia Pathophysiology of Neonatal Jaundice Jaundice is a common disorder in newborns and ca 3 Causes of jaundice Queensland Clinical Guideline: Neonatal jaundice Refer to online version, destroy printed copies after use Page 6 of 40 List of Tables Table 1 Pathophysiology . Jaundice is the yellowing of the skin and sclera due to abnormally elevated levels of bilirubin in the blood. It can be characterized into three different categories including pre-hepatic, intra-hepatic, or post-hepatic. Pre-hepatic and intra-hepatic causes are known as medica

jaundice must have their level of conjugated bilirubin measured. Preterm infants on long-term parenteral nutrition may develop conjugated jaundice which generally improves with the introduction of enteral feed and weaning of intravenous nutrition. Keywords: Neonatal jaundice, kernicterus, conjugated jaundice, phototherapy, exchange transfusio Overview. Neonatal jaundice is a condition that is characterized by the yellow discoloration of the skin and sclera of the newborn due to the accumulation of unconjugated bilirubin. Unconjugated hyperbilirubinemia is usually a transient physiologic phenomenon, but if blood bilirubin rises to very high levels, kernicterus can develop Patients require counsel regarding the physical appearance or symptoms of jaundice. In the case of neonatal jaundice, parents will need to know about the cause of physiologic or non-physiologic jaundice and the treatment options available for it. Patients with any change in mental or neural behavior should immediately consult with a physician Step 1: Is the baby yellow? Visual inspection during a thorough neonatal examination. Jaundice often starts in the eyes, spreads to the face and then drops down to the trunk, legs and feet. Remember it is harder to rule out jaundice in babies with darker skin, premature infants and those less than 36 hours old

There are several causes of hyperbilirubinemia and jaundice, including the following: Physiologic jaundice. Physiologic jaundice occurs as a normal response to the baby's limited ability to excrete bilirubin in the first days of life due to the immaturity of the liver. This will usually resolve by the first week of life history of neonatal jaundice.4 In addition to hyperbilirubinemia, earlier gestational age, hemolysis, sepsis, and low birth weight are associated with the development of bilirubi Learn more about the bilirubin levels and pathophysiology of neonatal jaundice (neonatal hyperbilirubinemia) for your medical studies and the prevention of kernicterus. Epidemiology and etiology of neonatal jaundice , clinical presentation , diagnostic workup and treatment . Read more here! Neonatal Jaundice (Neonatal Hyperbilirubinemia.

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Jaundice - SlideShar

Jaundice, a sign of elevated bilirubin levels, is common during the first weeks of life, especially among preterm newborns. Bilirubin, a product from the normal breakdown of red blood cells, is elevated in newborns for several reasons: Newborns have a higher rate of bilirubin production due to the shorter lifespan of red blood cells and higher red blood cell concentration compared to adults Key Points (continued): 3 UMHS Neonatal Hyperbilirubinemia Guideline 06/2020 Phototherapy Techniques (cont'd). Irradiance should be measured regularly. There is a lack of evidence to support the use of fiberoptic blanket alone. Phototherapy can be temporarily halted to allow for bonding and breastfeeding, when neonates are not considered high ris KEY WORDS: bilirubin, hyperbilirubinemia, jaundice, neonatal intensive care, newborn, phototherapy, premature infant P hototherapy is the use of visible light for the treatment of hyperbilirubinemia, or jaundice, in the newborn.1 It is perhaps the most com-mon nonroutine therapy applied in the newborn population. How phototherapy came to be is.

Pathophysiology of jaundice - SlideShar

Neonatal Jaundice PowerPoint PPT Presentation

In this study, we aimed to evaluate the effect of fetal-neonatal blood group on the severity of hemolysis and jaundice due to maternal-fetal ABO incompatibility. In a retrospective analysis of 166 cases with ABO hemolytic disease of the newborn, risk factors for the severity of jaundice were compared in infants with blood group A or B Neonatal jaundice is the condition of elevated bilirubin at the time of birth. Bilirubin is a yellowish pigment present in hemoglobin (responsible for carrying oxygen in Red Blood Cells). An increase in the concentration of bilirubin above 3 mg per dL of blood causes neonatal jaundice Neonatal jaundice is thought to occur due to the simultaneous occurrence of: In the vast majority of infants this normal, or physiological, jaundice causes no harm and clears spontaneously, usually reaching normal levels by about 10 days of age. It may persist for longer in babies who are exclusively breast-fed (breast-milk.

PPT - Jaundice – neonatal, prolonged and beyond PowerPoint

Video: PPT - Neonatal Jaundice PowerPoint presentation free to

PPT - Jaundice PowerPoint presentation | free to download Jaundice - My Free Prescription - Jaundice is a yellow mark of the skin, mucous membranes, and the whites of the eyes happened by enhancing the amounts of bilirubin in the blood Page 1 of 7,611 results for neonatal jaundice Shanghai JiaoTong University, School of Medicine Neonatal. Phototherapy is the use of visible light for the treatment of hyperbilirubinemia in the newborn. This relatively common therapy lowers the serum bilirubin level by transforming bilirubin into water-soluble isomers that can be eliminated without conjugation in the liver. The dose of phototherapy larg 1. Define pathologic jaundice in the neonate and describe the steps needed to evaluate a cholestatic infant. 2. Enumerate the most common and the most serious causes of conjugated hyperbilirubinemia in the neonatal period. 3. Promptly recognize infants with biliary atresia, and appropriately intervene Clinical Approach to Neonatal Jaundice PPT Presentation Summary : Jaundice becomes evident when the irubin levels rise above 2.0 to 2.5mg/dl Levels as high as 30 to 40mg/dl can occur with sever disease Jaundice occur It is very important for the nurse or the doctor examining an infant jaundice to have a very clear nursing care plan. It helps keep record of the diagnosis and treatment process. It is essential to seek neonatal jaundice care plan writing help to come up with a consistent care plan for the baby

Neonatal jaundice is a yellowish discoloration of the white part of the eyes and skin in a newborn baby due to high bilirubin levels. Other symptoms may include excess sleepiness or poor feeding. Complications may include seizures, cerebral palsy, or kernicterus.. About 60% of full term newborn and 80% of premature babies are jaundiced The clinical challenge is identifying the tiny minority with pathological neonatal jaundice from the large majority with benign physiological jaundice. There are important cues that jaundice may be pathological. Incidence and risk factors: It is clinically useful to classify jaundice according to the age of the baby when he/she become Pathophysiology of Jaundice Most bilirubin is produced when hemoglobin (Hb) is broken down into unconjugated bilirubin (and other substances). Unconjugated bilirubin binds to albumin in the blood for transport to the liver, where it is taken up by hepatocytes and conjugated with glucuronic acid to make it water soluble

Pathophysiology Of Jaundice Ppt, Ppt Neonatal Jaundice

Jaundice is a disease which causes the colour of the skin and the whites of the eye to turn yellow. The yellowing happens due to an excess of bilirubin in the blood, which can occur due to liver disease, excessive breakdown of red blood cells, or obstruction of the bile duct. If you notice symptoms. Physiologic Jaundice is a common disorder affecting infants shortly after birth. It is caused due to a decreased excretion of bilirubin from the baby's body. As a result, yellowing of the eyes, mucus, and skin is noticed. It is rarely severe or serious, and the condition is usually self-limiting Pathological neonatal jaundice can be caused by a number of factors, including [National Collaborating Centre for Women's and Children's Health, 2010; Queensland Health, 2019; BMJ Best Practice, 2020]: Blood group incompatibility (most commonly Rhesus or ABO incompatibility). Other causes of haemolysis. Sepsis. Bruising Jaundice develops due to increase the level of bilirubin and deposition under the skin and cause the yellow discoloration of the skin. Pathogenesis of neonatal jaundice includes physiologic process of bilirubin accumulation or pathological mechanism. The pathological jaundice may be acquired or inherited. Acquired neonatal jaundice include Rh.

Jaundice - Management of neonatal jaundice. Date last published: 09 September 2020. Jaundice (SBR >50 μmol /L) is one of the most common physical signs observed during the neonatal period. Approximately 50-60% of newborn infants will become jaundiced during the first week of life. This document is only valid for the day on which it is accessed However, there are many other causes of neonatal jaundice that can be more serious, and require further medical evaluation and intervention. A newborn that develops jaundice within the first 24 hours of life requires immediate medical attention. The following are some of the causes of neonatal jaundice

Obstructive jaundice- Introduction

Pathologic jaundice within the first 36 hours of life is usually due to excessive production of bilirubin. Hyperbilirubinemia is managed based on the infant's weight •Differentiate between physiological and pathological jaundice. •State causes of neonatal jaundice. •Discuss the pathophysiology of neonatal jaundice Neonatal jaundice can be classified as physiological and pathological and can have several causes such as breast milk feeding, blood group incompatibility, hemolysis, or genetic defects of enzymes. Jaundice that appears during the neonatal period. In the majority of cases, it appears in the first week of life and is classified as physiologic due to accelerated destruction of erythrocytes and liver immaturity. In a minority of cases it is classified as non-physiologic, appearing in the first twenty four hours after birth, and is associated. Of Jaundice Pathophysiology Of Jaundice referred presentation of jaundice pathophysiology of jaundice ebook that will present you worth, get the very best seller from us currently from several preferred authors. If you desire to funny books, lots of novels, tale, jokes, and more fictions collections are Page 2/8

Key Difference - Physiological vs Pathological Jaundice Yellowish discoloration of the mucosal layers of the body is defined as jaundice. In a healthy neonate, jaundice can appear because of increased hemolysis and the immaturity of the liver to rapidly metabolize the bilirubin produced during the process. This is known as physiological jaundice Jaundice - epidemiology, pathophysiology, diagnosis, treatment. Jaundice (icterus) is yellow pigmentation of tissues and body fluids due to elevated serum bilirubin. Bilirubin is formed from breakdown of the heme ring of hemoglobin molecules and hemoproteins, primarily the cytochromes. (1) The average daily production of total bilirubin in. Neonatal jaundice is a term for elevated total serum bilirubin in newborns and infants less than one month of age. In other words, neonatal Jaundice is the yellowish coloration of the skin and the white part of the eye (the sclera). 1 Neonatal jaundice occurs in 60 % of term healthy neonates and 80 % of preterm neonates.2 It results from having too much of substance called bilirubin in the blood Determinants of neonatal jaundice among neonates admitted to five referral hospitals in Amhara region, Northern Ethiopia: an unmatched case-control study Glucose-6-Phosphate Dehydrogenase Deficiency and the Benefits of Early Screenin

jaundice, it is entirely easy then, previously currently we extend the join to purchase and make bargains to download and install presentation of jaundice pathophysiology of jaundice as a result simple! offers an array of book printing services, library book, pdf and such as book cover design, text formatting and design, ISBN assignment, and. Jaundice in newborns is most commonly physiological or due to ABO/Rh hemolytic incompatibility. However, if jaundice is associated with dark urine and/or pale stools, it is suggestive of cholestasis. The sensitivity, specificity, and positive predictive value of pale stools for the detection of biliary atresia (BA) before 60 days a

Neonatal Jaundice: Background, Pathophysiology, Etiolog

Background Jaundice is a common symptom of inherited or acquired liver diseases or a manifestation of diseases involving red blood cell metabolism. Recent progress has elucidated the molecular mechanisms of bile metabolism, hepatocellular transport, bile ductular development, intestinal bile salt reabsorption, and the regulation of bile acids homeostasis. Main body The major genetic diseases. the neonatal period. 5.5 Developmental defects: Cerebral dysgenesis and neuronal migration disorders are rare causes of seizures in the neonatal period. 5.6 Miscellaneous: These causes include polycythemia, maternal narcotic withdrawal, drug toxicity (e.g. theophylline, doxapram), local anesthetic injection into scalp and phacomatosis (e.g SEMINAR 6: APPROACH TO NEONATAL JAUNDICE. Presenters: Addie Rabi Dhoshyini Yana Learning Objectives • Describe the physiology of bilirubin metabolism in the newborn period and physiological jaundice • Classify, investigate and treat neonatal conjugated and unconjugated hyperbilirubinaemia • Discuss the causes, investigations and management of prolong neonatal jaundice Physiology of. View NEONATAL+JAUNDICE.ppt from IDEO 101 at Al-Sirat Degree College. NEONATAL JAUNDICE Name- Shaheen Mohd Sultan Group- 7(B),4th-eng Teacher- Mahabat Mam Neonatal Jaundice • Hyperbilirubinemia i

Management Of Neonatal Jaundice PPT Presentation Summary : In recent Neonatal Network Trial, aggressive phototherapy compared to conservative phototherapy reduced both peak bilirubin and profound NDI at 18-22 months Physiologic Jaundice Disorders of Production Disorders of Hepatic Uptake Disorders of Conjugation Other Causes Differential Dx of Indirect Hyperbilirubinemia: Physiologic Jaundice: Progressive rise in total bilirubin between 48 and 120 hours of life (peaks at 72-96 hours) Due to higher postnatal load of bilirubin and lower amount of liver. Neonatal jaundice 2 In all babies: •check whether there are factors associated with an increased likelihood of developing significant hyperbilirubinaemia soon after birth •examine the baby for jaundice at every opportunity especially in the first 72 hours. When looking for jaundice (visual inspection) 1. M. Jeffrey Maisels, MB, BCh* 1. *Department of Pediatrics, William Beaumont Hospital, Royal Oak, Mich After reviewing this article, readers should be able to: 1. Understand the metabolism of bilirubin. 2. Describe the factors that place an infant at risk for developing severe hyperbilirubinemia. 3. Describe the physiologic mechanisms that result in neonatal jaundice

algorithm on management of neonatal jaundice viii 1. introduction1 2. risk factors 2 3. relationship between bilirubin 5 level and bilirubin encephalopathy/ kernicterus 4 methods of detecting jaundice and 7 assessing its severity 5. assessment components 11 6. indications for treatment 17 7. phototherapy18 8. exchange transfusion 21 9 Causes and Diagnosis of Neonatal Jaundice. The three most common causes of jaundice in neonates are hepatitis, biliary atresia, and choledochal cyst (, 2 6 7 13). US is the imaging modality of choice for differentiating among these conditions Understanding the pathophysiology of obstructive jaundice is. essential for proper evaluation in order to prevent a delay in. the diagnosis: a careful history and physical examination help. in.

PPT - Jaundice PowerPoint Presentation - ID:1131304Introduction and Anemia 2007

Click for pdf: Neonatal Jaundice Background The term jaundice comes from the root jaune, the French word for yellow. Jaundice is common in the neonatal period, affecting 50-60% of newborns. Jaundice is not a disease by itself, but rather, a sign that results from hyperbilirubinemia, the excessive accumulation of bilirubin in the blood Jaundice is a common symptom of inherited or acquired liver diseases of various causes. The underlying bio-chemical disturbance of jaundice is defined by direct or indirect hyperbilirubinemia. These two categories may represent different mechanisms causing jaundice. Indir-ect hyperbilirubinemia typically results from increase the causes and symptoms of this disorder (4). According to a study by Gordon, neonatal jaundice leads to the high prevalence of neurological and developmental disorders in infants, aged 18-32 months. Also, the mentioned study showed that approximately 4.3% of infants with jaundice cannot normally sit or stand (7) Pathophysiology Of Obstructive Jaundice & Anaesthesia PPT. Presentation Summary : Biliary sepsis is very common. Normally regress of bacteria from the intestine in the biliary system Pathophysiology. Jaundice results from high levels of bilirubin in the blood. Bilirubin is the normal breakdown product from the catabolism of haem, and thus is formed from the destruction of red blood cells.. Under normal circumstances, bilirubin undergoes conjugation within the liver, making it water-soluble.It is then excreted via the bile into the GI tract, the majority of which is egested.

Health-related Topics : Medical Biochemistry Tips (8

Jaundice, a yellow discoloration of the skin, sclera, mucous membranes and bodily fluids, is a common clinical finding in the first 2 weeks of neonatal life, occurring in up to 15% of breastfed. Arias first described breast milk jaundice (BMJ) in 1963. [1, 2] This condition is a type of neonatal jaundice associated with breastfeeding that is characterized by indirect hyperbilirubinemia in an otherwise healthy breastfed newborn that develops after the first 4-7 days of life, persists longer than physiologic jaundice, and has no other identifiable cause BACKGROUND Neonatal jaundice is one of the main causes of the patient's admission in the neonatal period and is potentially linked to morbidity. AIM This study aimed to determine the possible. Very often, the pathological structure of the placenta, the umbilical cord or the fetal membranes are the causes of primary neonatal asphyxia. Risk factors include premature rupture of amniotic fluid, premature detachment of the placenta, and improper positioning of the fetus' head during delivery Inherent neonatal deficiency of this enzyme is the principal etiology of physiologic jaundice. For the first 10 days of life, UDPGT is present at levels about 0.1% of adult values, and hyperbilirubinemia appears to be the primary stimulus to enzyme production